TET Protein
TET enzyme; Ten-eleven-translocation (TET) protein; Ten-eleven translocation (TET) methylcytosine dioxygenase
TET proteins, including TET1, TET2, and TET3, are a family of dioxygenases that catalyze the demethylation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), facilitating DNA demethylation. These enzymes share a common core catalytic domain at their C termini. TET3 is highly expressed in oocytes and fertilized zygotes but decreases during cleavage, while TET1 and TET2 expression increases during pre-implantation development. TET1 is crucial for development and intestinal stem cell function. TET2 mutations are frequently found in hematologic malignancies, such as myelodysplastic syndrome and acute myeloid leukemia. TET3 plays a significant role in demethylation processes, including zygote formation, embryogenesis, axon regeneration, and synaptic transmission[1][2].
References:
- [1]. Zhang X, et al. TET (Ten-eleven translocation) family proteins: structure, biological functions and applications. Signal Transduct Target Ther. 2023 Aug 11;8(1):297. [Content Brief]
- [2]. Yang J, et al. The roles of TET family proteins in development and stem cells. Development. 2020 Jan 15;147(2):dev183129. [Content Brief]
TET Protein Isoform Specific Products
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TET Protein Related Products (11)
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TET Protein Isoform Comparison
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Bobcat339
0 ImagesBobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.
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Bobcat339 hydrochloride
0 ImagesBobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.
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TETi76
0 ImagesCat. No.: HY-402410CAS No.: 1451750-73-4TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research.
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OAC1
0 ImagesOAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time.
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Tet1-Cys peptide
0 ImagesTet1-Cys peptide is a peptide with the sequence HLNILSTLWKYRC. Tet1 (HLNILSTLWKYR) (HY-P10998) can specifically bind to the neuronal ganglioside receptor GT1b, possessing neuronal targeting capabilities. The Tet1-Cys peptide sequence has an added Cys, which can be used for drug conjugation for research on drug delivery.
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Tet1 peptide
0 ImagesCat. No.: HY-P10998CAS No.: 270919-17-0
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Recombinant Ten-Eleven Translocase
0 ImagesCat. No.: HY-E70583Recombinant Ten-Eleven Translocase is a recombinant Fe(II)- and α-ketoglutarate-dependent dioxygenase. Recombinant Ten-Eleven Translocase converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), and then to 5-formylcytosine (5fC) and 5-carboxycytosine (5caC) through a series of oxidation reactions. Then, 5caC is further converted into uracil (U) through the action of a conversion agent or enzyme, and uracil (U) is converted into thymine (T) through PCR, thereby achieving single-base resolution and high-accuracy identification of DNA methylation sites.
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Succinic acid sodium
0 ImagesCat. No.: HY-W396714CAS No.: 14047-56-4Synonyms: Wormwood acid sodiumSuccinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research.
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